A landmark 2022 umbrella review in Molecular Psychiatry by Dr. Joanna Moncrieff analyzed 17 major reviews and found 'no consistent evidence' linking low serotonin to depression. Drug trials showed antidepressants are 'barely distinguishable from placebo.' Yet the chemical imbalance narrative, heavily promoted by pharmaceutical companies, drove SSRI prescriptions to over 70 million Americans. The serotonin theory was marketing masquerading as science.
The 'chemical imbalance' theory of depression was never proven, yet SSRIs were prescribed to millions based on it for 30+ years
βThere is no consistent evidence of there being an association between serotonin and depression, and no support for the hypothesis that depression is caused by lowered serotonin activity.β
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